nutrient

Arachidonic acid

Arachidonic acid is a long-chain omega-6 fatty acid found in animal foods and made from linoleic acid.

It is part of membrane phospholipids and can be released for synthesis of signalling mediators.

A downstream omega-6 member

Arachidonic acid can be supplied preformed or made from linoleic acid through elongation and desaturation. Its release from membranes feeds several mediator pathways, which have different effects and contexts.

Related topics

  • Polyunsaturated fat includes Arachidonic acid

    Arachidonic acid is a long-chain omega-6 polyunsaturated fatty acid.

  • Linoleic acid can be converted to Arachidonic acid

    Linoleic acid is a precursor in the omega-6 pathway that can produce arachidonic acid.

Worth knowing

  • No separate EFSA DRV. EFSA did not set a dietary reference value for arachidonic acid.

A closer look

Mediator pathways are context-specific

Arachidonic acid can be released from membrane phospholipids and converted into multiple mediator families with context-dependent actions.

Release feeds several mediator families

Arachidonic acid can enter multiple mediator pathways, so its biological effects depend on the enzyme route and tissue context.

References

Source-checked local draft.
Human editorial review pending.

  1. European Food Safety AuthorityScientific Opinion on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterolChecked 2026-09-05