nutrient

Menaquinone-4 (MK-4)

A specific menaquinone form of vitamin K found in some animal-derived foods and formed in human tissues.

MK-4 is one member of the K2 group. Its chemical identity should remain separate from other menaquinones such as MK-7.

What the form means

MK-4 is a menaquinone with a four-isoprenoid side chain and one member of the vitamin K2 group.

Forms

  • Menaquinone-4 (MK-4) is a form of Vitamin K.

    Menaquinone-4 (MK-4) is a named chemical form within its parent vitamin family.

Worth knowing

  • A specific K2 form. MK-4 is a menaquinone found in some animal-derived foods and formed in human tissues from phylloquinone. “K2” on its own does not tell you whether a product contains MK-4 or another menaquinone.

A closer look

The body can make some MK-4

MK-4 is unusual within the K2 group because the body can make it from K1 through a tissue conversion process. That pathway is different from the bacterial production associated with many longer-chain menaquinones, so K2 should not be treated as one uniform metabolic source.

References

Source-checked local draft.
Human editorial review pending.

  1. NIH Office of Dietary SupplementsVitamin K: Fact Sheet for Health ProfessionalsChecked 2026-09-05