nutrient

Methylcobalamin

A coenzyme form of vitamin B12 involved in methionine synthase activity.

Methylcobalamin is one of the metabolically active B12 forms. Product evidence and dose depend on the specific form and context.

What the form means

Methylcobalamin participates in the methionine synthase reaction and is one of the active coenzyme forms of B12.

Forms

  • Methylcobalamin is a form of Vitamin B12 (cobalamin).

    Methylcobalamin is a named chemical form within its parent vitamin family.

Worth knowing

  • One active coenzyme form. Methylcobalamin is a metabolically active form of vitamin B12 used in the methionine synthase reaction. It is one named form within the B12 family, not a separate nutrient.

A closer look

An active form is not proof of better absorption

A supplement can provide methylcobalamin directly, while other products provide cyanocobalamin that the body converts into active forms. NIH ODS does not find evidence that supplement absorption differs by B12 form, so “methyl” by itself is not proof of superior results.

References

Source-checked local draft.
Human editorial review pending.

  1. NIH Office of Dietary SupplementsVitamin B12: Fact Sheet for Health ProfessionalsChecked 2026-09-04