nutrient

5-MTHF (5-methyltetrahydrofolate)

A reduced folate form involved in one-carbon transfer and available in some supplements.

5-MTHF is a folate form found in the body and some products. Product labels may use different salt names and amounts.

What the form means

5-MTHF participates in folate-dependent one-carbon metabolism and is available in some supplement products.

Forms

  • 5-MTHF (5-methyltetrahydrofolate) is a form of Vitamin B9 (folate).

    5-MTHF (5-methyltetrahydrofolate) is a named chemical form within its parent vitamin family.

Worth knowing

  • A reduced folate form. 5-MTHF, or 5-methyltetrahydrofolate, is a folate form present in the body and used in some supplement products. Labels may call it L-methylfolate or name a salt such as calcium 5-MTHF.

A closer look

It participates in one-carbon transfer

5-MTHF carries a one-carbon unit used in the remethylation of homocysteine to methionine. Vitamin B12 also participates in this reaction. Knowing that a form is used in the body does not establish that taking it as a supplement produces better results than folic acid.

References

Source-checked local draft.
Human editorial review pending.

  1. NIH Office of Dietary SupplementsFolate: Fact Sheet for Health ProfessionalsChecked 2026-09-05