body system
Bone
Bone tissue is continuously built and remodeled.
Educational draft · Human scientific and editorial review pending. About review status
About Bone
Vitamin D supports normal bone mineralization by helping maintain calcium and phosphate availability. This is a physiological role, not a promise that supplementation prevents fractures for everyone.
Where does vitamin D come from—and where does it go?Related topics
Vitamin D supports mineralisation in Bone
Vitamin D helps maintain the calcium and phosphate concentrations needed for normal bone mineralization and remodeling.
Evidence: Established · Source checked 2026-09-04 · Sources: NIH Office of Dietary Supplements: Vitamin D: Fact Sheet for Health Professionals; European Food Safety Authority: Vitamin D: EFSA sets dietary reference values
Magnesium supports function of Bone
Magnesium contributes to bone structure and to processes involved in bone metabolism.
Evidence: Established · Source checked 2026-09-05 · Sources: NIH Office of Dietary Supplements: Magnesium: Fact Sheet for Health Professionals
Manganese supports formation of Bone
Manganese-dependent enzymes participate in bone and connective-tissue formation.
Evidence: Established · Source checked 2026-09-05 · Sources: NIH Office of Dietary Supplements: Manganese: Fact Sheet for Health Professionals
Vitamin K supports protein activation in Bone
Vitamin K activates proteins involved in bone metabolism through gamma-carboxylation.
Evidence: Established · Source checked 2026-09-05 · Sources: NIH Office of Dietary Supplements: Vitamin K: Fact Sheet for Health Professionals
Calcium forms mineral in Bone
Calcium phosphate mineral provides much of the structural material in bone.
Evidence: Established · Source checked 2026-09-05 · Sources: NIH Office of Dietary Supplements: Calcium: Fact Sheet for Health Professionals
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Phosphorus forms mineral with calcium in Bone
Phosphate combines with calcium in the mineral phase of bone and teeth.
Evidence: Established · Source checked 2026-09-05 · Sources: NIH Office of Dietary Supplements: Phosphorus: Fact Sheet for Health Professionals
Fluoride is incorporated into mineralised tissue in Bone
Fluoride can be incorporated into mineralised tissue and helps tooth enamel resist acid dissolution.
Evidence: Established · Source checked 2026-09-05 · Sources: NIH Office of Dietary Supplements: Fluoride: Fact Sheet for Health Professionals
References
Source-checked local draft.
Human editorial review pending.
- NIH Office of Dietary Supplements (opens in new tab)Vitamin D: Fact Sheet for Health ProfessionalsChecked 2026-09-05
- European Food Safety Authority (opens in new tab)Vitamin D: EFSA sets dietary reference valuesChecked 2026-09-04
- NIH Office of Dietary Supplements (opens in new tab)Magnesium: Fact Sheet for Health ProfessionalsChecked 2026-09-04
- NIH Office of Dietary Supplements (opens in new tab)Manganese: Fact Sheet for Health ProfessionalsChecked 2026-09-05
- NIH Office of Dietary Supplements (opens in new tab)Vitamin K: Fact Sheet for Health ProfessionalsChecked 2026-09-05
- NIH Office of Dietary Supplements (opens in new tab)Calcium: Fact Sheet for Health ProfessionalsChecked 2026-09-04
- NIH Office of Dietary Supplements (opens in new tab)Phosphorus: Fact Sheet for Health ProfessionalsChecked 2026-09-05
- NIH Office of Dietary Supplements (opens in new tab)Fluoride: Fact Sheet for Health ProfessionalsChecked 2026-09-05